TABLE 5.

The residual amounts of Pep05 derivatives at different time intervals following trypsin incubation.

Peptides	Relative peak area (%)1
	1 h	5 h	18 h	24 h
DP06	82.99 ± 1.41	40.89 ± 1.89	15.60 ± 1.52	6.36 ± 1.50
UP11	87.39 ± 3.05	47.43 ± 3.82	∼0	ND2
UP13	95.38 ± 0.88	38.22 ± 1.62	0.66 ± 0.16	ND
UP14	74.61 ± 3.25	61.12 ± 3.39	1.37 ± 0.41	ND
UP15	59.46 ± 2.97	19.34 ± 1.65	4.36 ± 0.37	ND

¹Take the peak area of 0 h as 100% for each peptide and the remained amounts were calculated by relative peak area monitored by HPLC. The peak area of peptide was obtained by subtraction of background peak areas in blank matrix. Results represent the mean (± standard deviation SD). Each experiment was performed in triplicate. ²ND means “not determined”.