TABLE 9.

Cytotoxicity of Pep05 and derivatives against human erythrocytes and mouse macrophage RAW 264.7 cells.

Peptides	Hemolysis rate (%)1			IC50 value (μM) RAW 264.7
	32 μM	64 μM	128 μM
Pep05	9.201.01	34.39 ± 1.49	49.18 ± 2.01	13.42 ± 2.85
LP01	7.660.46	29.58 ± 0.83	37.14 ± 1.29*	16.55 ± 3.79
LP02	9.150.37	24.18 ± 2.01	45.40 ± 2.40	14.43 ± 1.44
DP03	9.510.27	41.96 ± 4.14	51.55 ± 3.89	45.02 ± 5.96*
DP04	11.330.63	38.84 ± 1.61	58.26 ± 1.84	34.72 ± 3.69*
DP05	5.380.15	30.09 ± 1.56	45.07 ± 2.93	32.70 ± 3.44*
DP06	10.490.48	37.14 ± 2.73	59.99 ± 2.41	48.77 ± 6.97*
UP07	6.130.41	18.23 ± 2.76*	30.10 ± 2.61*	17.54 ± 2.99
UP08	16.231.45	52.49 ± 2.25*	86.84 ± 1.24*	14.56 ± 2.96
UP09	19.020.08*	55.99 ± 3.75*	95.99 ± 2.10*	26.21 ± 1.80*
UP10	22.521.07*	56.82 ± 2.62*	95.02 ± 1.84*	22.82 ± 4.65
UP11	70.732.66*	95.65 ± 2.31*	∼100.00*	28.34 ± 5.80*
UP12	23.491.15*	45.13 ± 1.95*	∼100.00*	21.24 ± 2.42
UP13	17.411.82*	41.03 ± 1.38	∼100.00*	21.74 ± 4.14
UP14	31.170.85*	66.51 ± 3.14*	74.68 ± 1.34*	13.97 ± 2.67
UP15	20.590.49*	54.16 ± 2.02*	97.86 ± 3.07*	28.69 ± 3.52*

¹Results represent the mean (± standard deviation SD) of three independent experiments, each performed in triplicate. * Indicates a statistically significant difference when modified peptides were compared to Pep05 (P < 0.05 by ANOVA; n = 3).