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. 2020 Nov 12;8:583919. doi: 10.3389/fcell.2020.583919

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Copyright © 2020 Rees, Tandun, Yau, Zachos and Steiner.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential for use of intestinal organoids as “grafts” for the damaged epithelium. Recent advances in epithelial regeneration via organoid transplantation have shown that it could be possible to recover a damaged intestine or colon with autologous organoid transplantation. One approach to improve efficacy in engraftment and recovery post damage would be to isolate intestinal stem cells (ISCs) from the inflamed tissue, or if possible, non-inflamed adjacent tissue, modify target genes via CRISPR or equivalent recombinant techniques, expand the modified ISCs in vitro, and engraft back into the damaged area to recover the injured area. Tissue scaffolds, either synthetic or derived from human intestinal resections, could facilitate growth and proper cellular alignment.