Table 1.
Association statistics for lead maternal preeclampsia variants.
| Discovery | Follow-up | Combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N = 9515/157,719 | N = 2635/6379 | N = 12,150/164,098 | ||||||||
| SNP | Locus | EA/OA | EAFEUR | EAFCA | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P |
| rs259983 | ZNF831/20q13 | C/A | 0.15 | 0.08 | 1.15 (1.09–1.22) | 2.2 × 10−7 | 1.25 (1.11–1.40) | 1.4 × 10−4 | 1.17 (1.11–1.23) | 2.9 × 10−10 |
| rs1421085 | FTO /16q12 | C/T | 0.41 | 0.28 | 1.13 (1.08–1.17) | 2.0 × 10−9 | 1.06 (0.99–1.14) | 0.089 | 1.11 (1.07–1.15) | 1.2 × 10−9 |
Locus refers to the nearest gene and chromosomal location.
EA effect allele, OA other allele: EAFEUR and EAFCA, effect allele frequency in the meta-analysis of European and Central Asian subjects, respectively, N is the number of individuals in the analysis: cases/controls, OR odds ratio, CI confidence interval, P P-values are two-sided and derived from a fixed-effect meta-analysis of effects and adjusted for genomic control.