Table 2.
Association statistics for blood pressure variants that associate with preeclampsia.
| Discovery | Follow-up | Combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| N = 9515/157,719 | N = 2635/6379 | N = 12,150/164,098 | ||||||||
| SNPa | Locus | EA/OA | EAFEUR | EAFCA | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P |
| rs1918975 | MECOM /3q26 | T/C | 0.6 | 0.61 | 1.12 (1.07–1.16) | 2.5 × 10−8 | 1.06 (0.99–1.14) | 0.094 | 1.10 (1.07–1.14) | 1.2 × 10−8 |
| rs419076b | MECOM /3q26 | T/C | 0.47 | 0.32 | 1.09 (1.05–1.13) | 7.7 × 10−6 | ||||
| rs1458038 | FGF5 /4q21 | T/C | 0.32 | 0.37 | 1.12 (1.07–1.16) | 4.2 × 10−8 | 1.07 (1.00–1.15) | 0.063 | 1.11 (1.07–1.15) | 1.2 × 10−8 |
| rs16998073b | FGF5 /4q21 | T/A | 0.31 | 0.34 | 1.12 (1.07–1.17) | 8.8 × 10−8 | ||||
| rs10774624 | SH2B3 /12q24 | G/A | 0.43 | 0.22 | 1.11 (1.08–1.16) | 7.0 × 10−8 | 1.08 (0.99–1.17) | 0.072 | 1.11 (1.07–1.15) | 1.7 × 10−8 |
| rs3184504b | SH2B3 /12q24 | T/C | 0.44 | 0.22 | 1.11 (1.07–1.16) | 5.3 × 10−7 | ||||
Locus refers to the nearest gene and chromosomal location.
EA effect allele, OA other allele: EAFEUR and EAFCA, effect allele frequency in the meta-analysis of European and Central Asian subjects, respectively, N is the number of individuals in the analysis: cases/controls, OR odds ratio, CI confidence interval, P P-values are two-sided and derived from a fixed-effect meta-analysis of effects and adjusted for genomic control.
aCorrelation (r2) between variants in European and Kazakh data: chr3: 0.36 and 0.12; chr4: 0.94 and 0.83; chr12: 0.88 and 0.97, respectively.
bLead BP variants at each locus as specified in Evangelou et al.16.