Table 1.

Description of the variables and parameters for the model system including the assigned parameter values and specification of units.

Variable	Description
NTC $(\overline{x},t)$	Number of tumor cells in the voxel at position $\overline{\text{x}}$ at time $\text{t}$
$D(\overline{x},t)$	Diffusion coefficient of tumor cells, where D $(\overline{x},t)=D_{0}exp(-\gamma {\sigma }_{\mathit{vm}}(\overline{x},t))$(mm2/day)
${\sigma }_{\mathit{vm}}$	Von Mises stress (kPa)
$\stackrel{\rightharpoonup }{u}$	Displacement vector due to tumor cell growth (mm)
$G$	Shear modulus due to breast tissue properties, where G $=E/(2(1-\nu ))$ (kPa)
$C_{\text{tissue}}^{\text{drug}}(\overline{x},t)$	Concentration of drug in the tissue in the voxel at position $\overline{x}$ at time $\text{t}$ (dimensionless)

Parameter	Description	Value
${\text{D}}_0$	Diffusion coefficient of tumor cells without stress	Calibrated, mm2/day
$\gamma$	Mechanical coupling coefficient for stress	Assigned at 2.0 × 10–3 (1/kPa)
$\nu$	Poisson’s ratio	Assigned, 0.45 (dimensionless)
$E$	Young’s modulus for adipose, fibroglandular, and tumor tissues	Assigned, 2 kPa, 4 kPa, and 20 kPa, respectively
$\lambda$	Coupling constant for displacement of tumor cells	Assigned as 2.5 × 10–3 (dimensionless)39
$k$($\overline{x}$)	Proliferation rate of tumor cells per voxel	Calibrated, 1/day
$\theta$	Carrying capacity of tumor cells in the voxel at position $\overline{x}$	Calculated, 2.02 × 106 cells
$\alpha$	Efficacy of the chemotherapy	Calibrated, 1/day
$\beta$	Drug exponential decay rate	Calibrated, 1/day
$\mu$	Efficacy of the targeted therapy	Calibrated, 1/day