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. 2020 Nov 12;10:588862. doi: 10.3389/fonc.2020.588862

Table 2.

Predictive factors of SRE onset.

Time to SRE Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
Gender Female
Male
0.713 0.451–1.125 0.146
Age at diagnosis ≥50
<50
0.801 0.399–1.608 0.533
Smoking status Yes
No/Unknown
1.425 0.893–2.273 0.137
Performance status (ECOG) ≥2
0–1
2.103 1.037–4.263 0.039 2.124 1.046–4.313 0.037
EGFR mutation ex 19 Yes
No
0.974 0.601–1.580 0.916
Number of metastatic sites Only BM
2
≥3
0.517
0.744
0.127–2.112
0.357–1.551
0.499
0.358
0.430
Synchronous mets Yes
No
0.963 0.572–1.622 0.888
Visceral mets Yes
No
1.233 0.718–2.118 0.448
Lung mets Yes
No
0.931 0.737–1.177 0.550
Liver mets Yes
No
1.741 1.070–2.833 0.026 1.946 1.169–3.239 0.010
Lymph nodes Yes
No
1.030 0.612–1.733 0.912
SNC mets Yes
No
1.308 0.829–2.064 0.248
Adrenal mets Yes
No
0.676 0.325–1.407 0.295
Number of bone mets sites 1–2
3–4
5–10
0.671
0.691
0.382–1.178
0.374–1.275
0.337
0.165
0.237
Hemoglobin ≤12 g/dl (women);
≤14 (men)
Normal value
0.976 0.521–1.830 0.939
ALP ≥220 U/I
Normal value
1.725 0.798–3.729 0.166
LDH ≥300 U/I
Normal value
0.921 0.450–1.885 0.821

Univariate and multivariate analyses of risk factors associated with SRE occurrence according to Cox’s proportional hazards regression model (SRE, skeletal related event).

Bold values denote statistical significance at the p < 0.005 level.