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In silico evidence for novel variants.
| Gene | Variant | GERP | Phast Cons | PolyPhen2 | CADD | gnomAD NFE (%) | gnomAD AFR (%) | gnomAD Lat (%) | gnomAD EAS (%) |
|---|---|---|---|---|---|---|---|---|---|
| LRRK2 | D734N | 5.94 | 0.579 | Probably damaging | 25.5 | 0 | 0 | 0.00003 | 0 |
| P1480L | 5.53 | 0.935 | Probably damaging | 29 | – | – | – | – | |
| R1941H | 4.85 | 1.000 | Possibly damaging | 23.6 | 0.00019 | 0.00004 | 0.00028 | 0.00005 | |
| GBA | S310G | 3.51 | 0.985 | benign | 26.5 | 0 | 0.00004 | 0 | 0.00020 |
gnomAD, genome aggregation database; NFE, non-Finish Europeans; AFR, African; Lat, Latinos; EAS, East Asian.
