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. 2020 Nov 12;12:576678. doi: 10.3389/fnagi.2020.576678

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Copyright © 2020 Robin, Evans, Hauser, Wren and Zembrzycki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Human iPSC neurons as a potential tool to study neurodegenerative and other CNS diseases. (A) Expression profiles—based on the RNA-Seq dataset described in Figure 2—for genes linked to selected neurodegenerative diseases. Each point represents an independent replicate (n = 4 independent replicates per time point), and the line for each graph shows a LOESS model of the data. The colored stripe on the y-axis indicates the quartile of count values shown in Figure 2A. Alzheimer’s Disease (AD), Parkinson’s Disease (PD), amyotrophic lateral sclerosis (ALS), frontotemporal lobe dementia (FTD). (B) Expression of three PGRN receptor genes—EPHA2, SORT1, and TNFRSF1A—in untreated GNs. (C) Expression of BDNF, NGF, and their receptors—NGFR (NGF receptor gene) and NTRK1–3 (BDNF receptor genes) in untreated GNs. Data in panels (B,C) are displayed as in Figure 2B.