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. 2020 Nov 12;14:580206. doi: 10.3389/fncel.2020.580206

FIGURE 1.

FIGURE 1

OM-MSCs ameliorated neurological deficit and inhibited neuronal apoptosis in an MCAO animal model. (A) Schematic representation of the experimental design for in vivo experiments. (B) The balance beam test, (C) the rotarod test, and (D) the modified neurological severity score (mNSS) test were performed before MCAO and on 3, 7, and 14 days after MCAO (n = 7/group at 3 and 7 days; n = 5/group at 14 days). (E,F) The cerebral infarct volume, assessed by TTC staining of coronal brain sections after MCAO (n = 3). (G) Neuronal apoptosis in the ipsilateral cortex as detected by NeuN and TUNEL immunofluorescence staining after MCAO. (H) Quantification of NeuN and terminal transferase-mediated dUTP nick end labeling (TUNEL) double-stained cells (n = 3). All data are displayed as mean ± SEM. (∗P < 0.05, ∗∗P < 0.01 vs. sham-operated, #P < 0.05, ##P < 0.01 vs. MCAO + saline).