Fig. 4.

Treatment of Tg4510 mice with dabigatran causes widespread differences in protein expression. Proteomic expression differences between wild type mice, Tg4510 mice (Tg-Vehicle), and Tg4510 mice treated with dabigatran (Tg-Dabigatran) are detected by LC-MS/MS SWATH analysis. Functional categories of proteins that show significant expression differences are shown as follows: (A) coagulation cascade, (B) cell signaling, and (C) inflammation-related. Mean ± SEM (n = 5), statistical differences determined by multiple t-tests, *p ≤ 0.05 vs. Wild Type, ^#p ≤ 0.05 vs. Tg-Vehicle.