Fig. 5.

Treatment of Tg4510 mice with dabigatran alters expression of proteins related to Alzheimer's disease pathology. Proteomic expression differences between wild type mice, Tg4510 mice (Tg-Vehicle), and Tg4510 mice treated with dabigatran (Tg-Dabigatran) are detected by LC-MS/MS SWATH analysis. (A) classic AD-associated proteins and (B) proteins determined by literature search to be altered in sporadic AD or tau pathology that show significant expression differences are shown. Mean ± SEM (n = 5), statistical differences determined by multiple t-tests, *p ≤ 0.05 vs. Wild Type, ^#p ≤ 0.05 vs. Tg-Vehicle.