Table 1.

Ratio of phosphorylated tau to total tau is decreased in Tg4510 mice treated with dabigatran. Brain homogenates from Tg4510 mice (Tg-Vehicle), and Tg4510 mice treated with dabigatran (Tg-Dabigatran) were analyzed by western blot for total tau, tau S396, and tau S416. The ratio of phosphorylated tau to total tau was calculated for S396 and S416. Values presented as Mean ± SEM. Significance was determined by student's t-test, *p ≤ 0.05.

Tau phosphorylation site	Tg-Vehicle	Tg-Dabigatran	p value (significance)
S396	1.010 ± .2061	0.6425 ± .2423	0.0163 (*)
S416	1.005 ± .2938	0.6656 ± .2358	0.0103 (*)