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. 2020 Nov 12;7:566388. doi: 10.3389/fmed.2020.566388

Table 2.

Hemoglobin (Hb), hematocrit, oxygen saturation (SaO2), oxygen saturation (pO2), arterial oxygen content (CaO2), venous oxygen content (CvO2), oxygen delivery, (DO2); oxygen consumption, (VO2), at baseline (37°CBL), during and after rewarming (30°CRW, and 37°CRW) from hypothermia in untreated and treated rats with levosimendan or nitroprusside (each group n = 7).

Parameter Group 37°CBL 30°CRW 37°CRW
Hb (g/dL) Control 12.56 ± 0.96 14.69 ± 0.25¤ 13.27 ± 0.84¤
Levosimendan 12.86 ± 1.18 14.29 ± 0.36¤ 13.01 ± 0.88¤
Nitroprusside 12.13 ± 0.71 14.04 ± 0.32¤ 12.77 ± 0.62¤
Hct (%) Control 38.63 ± 2.93 45.04 ± 0.74¤ 40.80 ± 2.55¤
Levosimendan 39.59 ± 3.53 43.80 ± 1.10¤ 39.99 ± 2.73¤
Nitroprusside 37.37 ± 2.12 43.13 ± 0.97¤ 39.29 ± 1.85¤
SaO2 (%) Control 86.29 ± 8.93 95.10 ± 0.77¤ 91.80 ± 4.17¤
Levosimendan 88.46 ± 3.46 91.66 ± 2.53 92.13 ± 3.71
Nitroprusside 91.67 ± 2.98 94.76 ± 0.55 91.17 ± 4.28
pO2 (kPa) Control 9.77 ± 2.39 17.38 ± 1.41 12.22 ± 2.54¤
Levosimendan 9.55 ± 1.01 15.28 ± 2.38 11.12 ± 1.87¤
Nitroprusside 12.16 ± 0.70 17.61 ± 0.85 12.31 ± 0.73¤
CaO2 (mg/dL) Control 14.71 ± 1.61 18.98 ± 0.39 16.58 ± 0.74
Levosimendan 15.49 ± 1.89 17.92 ± 0.79 16.32 ± 1.35
Nitroprusside 15.16 ± 0.70 18.25 ± 0.48 15.88 ± 1.03
DO2 (mg/min) Control 1,180 ± 142 766 ± 54¤ 784.5 ± 89¤
Levosimendan 1,281 ± 117 935 ± 51¤* 1083 ± 81¤*
Nitroprusside 1,235 ± 103 820 ± 68¤ 866 ± 111¤
VO2 (mg/min) Control 465 ± 40
Levosimendan 586 ± 109*
Nitroprusside 521 ± 110
pH Control 7.35 ± 0.03 7.22 ± 0.03¤ 7.30 ± 0.04¤
Levosimendan 7.35 ± 0.04 7.22 ± 0.01¤ 7.33 ± 0.03¤
Nitroprusside 7.38 ± 0.02 7.20 ± 0.02¤ 7.28 ± 0.03¤
pCO2 (kPa) Control 5.01 ± 0.88 5.01 ± 0.42 4.11 ± 0.56¤
Levosimendan 5.07 ± 0.26 5.50 ± 0.22 4.31 ± 0.38¤
Nitroprusside 4.52 ± 0.49 5.50 ± 0.17¤ 4.63 ± 0.34
Lactate (mmol/L) Control 0.90 ± 0.51 2.97 ± 0.23¤ 3.64 ± 0.84¤
Levosimendan 0.87 ± 0.51 3.01 ± 0.41¤ 3.26 ± 0.67¤
Nitroprusside 0.63 ± 0.19 3.93 ± 0.31¤* 4.10 ± 0.52¤
BE (mmol) Control −4.60 ± 2.31 −11.80 ± 0.57¤ −10.16 ± 1.96¤
Levosimendan −3.94 ± 2.22 −10.23 ± 0.68¤ −8.41 ± 1.12¤
Nitroprusside −4.93 ± 1.45 −11.11 ± 0.67¤ −9.57 ± 1.07¤
HCO3- (mmol/L) Control 20.44 ± 1.52 15.00 ± 0.58¤ 16.54 ± 1.46¤
Levosimendan 21.02 ± 1.87 15.82 ± 0.46¤ 17.80 ± 0.90¤
Nitroprusside 20.53 ± 1.01 15.25 ± 0.53¤ 16.72 ± 0.84¤

Values are mean ± SD.

*

P < 0.05 vs. control group at corresponding temperatures.

P < 0.05 vs. levosimendan group at corresponding temperatures.

¤

P < 0.05 vs. 37°CBL within-group (Holm–Sidak method).