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Tandospirone, in a dose-dependent manner, alleviates elevated self-grooming behavior in male+/− (HET) mice. (A) Tandospirone significantly reduced grooming behavior in HET mice at doses of 0.06 and 0.3 mg/kg, but not 0.01 mg/kg. (B) Tandospirone at the 0.30-mg/kg dose reduced the number of line crossings in both wildtype (WT) and HET mice. **P < .01 vs WT VEH, ++P < .01 vs HET VEH, +P < .05 vs HET VEH.
