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. 2020 Sep 23;29(19):3249–3265. doi: 10.1093/hmg/ddaa212

Figure 1.

Figure 1

Purkinje neuron degeneration is delayed in the nodular zone of ATXN1[82Q] mice. (A) Diagram outlining the anterior cerebellar lobules (yellow dotted line) and nodular zone (blue dotted line). (B and C) Total Purkinje neuron capacitance was measured in the anterior cerebellum (B) and nodular zone (C) of ATXN1[82Q] mice and wild-type controls at P24, P35 and P105. (D and E) Molecular layer thickness, a measurement which reflects the length of Purkinje neuron dendrites, was measured in the anterior cerebellum (D) and nodular zone (E) of ATXN1[82Q] mice and wild-type controls at P35, P105 and P175. (F and G) Cell number was measured in the anterior cerebellum (F) and nodular zone (G) of ATXN1[82Q] mice and wild-type controls at P35, P105 and P175. *Denotes P < 0.05, ***denotes P < 0.001, ns denotes P > 0.05; two-way repeated-measures ANOVA with Holm-Sidak correction for multiple comparisons.