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Involved and converging pathways targeted by DS and DR. The drugs identified by DS and DR influence and converge on a limited number of cellular and molecular pathways, that in turn act on specific districts, in particular involving MNs, NMJs and skeletal muscles. Created with BioRender software. DR, drug repositioning; DS, drug screening; MN, motor neuron; NMJ, neuromuscular junction; SMN, survival motor neuron.
