Table 1.
Comparison of significantly over-represented ASD-relevant canonical pathways in three phenotypic subgroups of ASD (Language, Intermediate, and Mild).
| Ingenuity canonical pathways | Language | Intermediate | Mild |
|---|---|---|---|
| (implicated in ASD) | –log(p-value)* | ||
| Axonal Guidance Signaling | 3.61 | 1.44 | |
| Protein Kinase A Signaling | 3.44 | ||
| Actin Cytoskeleton Signaling | 3.33 | ||
| CDK5 Signaling | 3.22 | ||
| cAMP-mediated signaling | 2.69 | 1.67 | |
| Androgen Signaling | 2.46 | ||
| Synaptogenesis Signaling Pathway | 2.03 | 2.14 | |
| Melatonin Signaling | 2.02 | ||
| VDR/RXR Activation | 2.00 | ||
| Ephrin Receptor Signaling | 1.99 | ||
| Neuregulin Signaling | 1.93 | 1.78 | 2.36 |
| GABA Receptor Signaling | 1.93 | ||
| Gap Junction Signaling | 1.90 | ||
| CREB Signaling in Neurons | 1.84 | ||
| Synaptic Long Term Depression | 1.74 | ||
| PI3K/AKT Signaling | 1.66 | ||
| Synaptic Long Term Potentiation | 1.62 | ||
| Estrogen Receptor Signaling | 1.58 | ||
| Neurotrophin/TRK Signaling | 1.44 | ||
| ERK/MAPK Signaling | 1.41 | ||
| Netrin Signaling | 1.71 | ||
| PTEN Signaling | 1.39 | ||
*
Negative logarithm of the Fisher Exact p-value indicating the probability that the indicated pathway is not over-represented among the genes in the respective datasets. A –log(p-value) of 1.3 is equivalent to a p-value of 0.05. Only significant values are shown.