Table 2.

Comparison of significantly over-represented neurological functions and diseases in three phenotypic subgroups of ASD as well as in the combined case group.

Neurological diseases and functions	Language	Intermediate	Mild	Combined
	–log(p-value)*
Morphology of nervous system	6.49	4.52		3.09
Organization of cytoskeleton	6.03
Motor dysfunction or movement disorder	5.82
Neurological signs	5.60
Neurotransmission	5.59	3.68		2.37
Movement Disorders	5.58
Schizophrenia spectrum disorder	5.35		3.16
Severe psychological disorder	5.11
Abnormal morphology of nervous system	4.90	4.11		2.32
Cognition	4.89	3.87		2.99
Synaptic transmission	4.73	3.22
Memory	4.36	2.80
Potentiation of synapse	4.12
Morphology of brain	3.93	3.27
Learning	3.90	2.92		2.78
Neuronal cell death	3.87
Cognitive impairment	3.86
Long-term potentiation	3.83
Development of neurons	3.77		2.54
Organization of actin cytoskeleton	3.71
Growth of neurites	3.64
Neuritogenesis	3.38
Outgrowth of neurites	3.24
Secretion of neurotransmitter	3.17		3.40
Morphology of dendritic spines	3.09
Polarization of neurites	3.04
Complete agenesis of corpus callosum		3.67
Extension of dendrites		3.33
Sensory disorders		3.25
Epilepsy or neurodevelopmental disorder			4.58	2.90
Seizure disorder			3.41
Epilepsy			3.35
Polarization of neuroglia			3.18
Complexity of dendritic trees				4.10
Migration of neurons				3.46
Size of neurons				3.40
Size of dendritic trees				3.38
Guidance of axons				3.19
Sensory system development				3.06
Emotional behavior				3.04

^*Negative logarithm of the Fisher Exact p-value which indicates the probability that the indicated disease or function is not over-represented in the respective dataset of genes. A –log(p-value) cutoff of 3 which is equivalent to a p-value of 0.001 was used to select diseases and functions from each group shown here.