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. 2020 Oct 22;11:544647. doi: 10.3389/fphar.2020.544647

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Copyright © 2020 Wu, Yang, Gao, Yi, Zhang and Chen

This is an open-access article distributed under the terms of the Creative Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytotoxic effect of shikonin on human colon cancer cell lines. (A) HT29 cells. (B) HCT116 cells. (C) SW620 cells. (D) SW480 cells. (E) Cytotoxic effect of shikonin under the selected dosages on SW620 cells for 24, 48, and 72 h. Data are expressed as mean ± SD (n = 3). (F) Structure of shikonin.