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. 2020 Oct 22;11:544647. doi: 10.3389/fphar.2020.544647

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Copyright © 2020 Wu, Yang, Gao, Yi, Zhang and Chen

This is an open-access article distributed under the terms of the Creative Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antitumor activity of shikonin in the xenograft mouse model. (A) Photograph of the tumor volume in three groups. (B) Tumor inhibitory rate of shikonin in nude mice ( $\bar{x} \pm s$ , n = 8). *p < 0.05, **p < 0.01, ***p < 0.001 vs. control group only. (C) Score plot of OPLS-DA in positive mode from tumor tissue metabolomics data. (D) Score plot of OPLS-DA in negative mode from tumor tissue metabolomics data.