TABLE 1.
Identification results of significant differential metabolites in cell samples.
| Metabolite | MZ | RT | VIP | p-value a | FDR b | Mode |
|---|---|---|---|---|---|---|
| Guanosine monophosphatec | 364.06442 | 1.22 | 1.78 | 3.28E-05 | 4.39E-03 | Positive |
| Threonic acidd | 135.03034 | 3.17 | 1.29 | 3.12E-04 | 9.55E-03 | Negative |
| Adenined | 134.04642 | 2.73 | 6.86 | 6.18E-04 | 6.30E-03 | Negative |
| Histaminec | 112.08709 | 22.81 | 1.04 | 6.47E-04 | 6.20E-03 | Positive |
| Xanthosined | 283.06979 | 4.08 | 1.58 | 1.68E-03 | 2.47E-02 | Negative |
| N1-Acetylspermidinec | 188.17543 | 0.86 | 2.23 | 2.73E-03 | 2.89E-02 | Positive |
| Inosinic acidd | 347.04152 | 1.23 | 4.80 | 2.86E-03 | 3.21E-02 | Negative |
| Adenosine monophosphatec | 346.05737 | 1.18 | 9.01 | 3.39E-03 | 3.30E-02 | Negative |
| Deoxyguanosinec | 266.09071 | 2.73 | 4.00 | 3.40E-03 | 3.32E-02 | Negative |
| Ornithined | 131.08181 | 0.90 | 1.42 | 4.07E-03 | 3.40E-02 | Negative |
| Uridine 5′-monophosphatec | 347.02444 | 1.08 | 1.09 | 4.46E-03 | 3.25E-02 | Positive |
| 5-Hydroxy-N-formylkynureninec | 251.06913 | 1.44 | 1.05 | 4.87E-03 | 3.25E-02 | Positive |
| Pyroglutamic acidd | 130.04983 | 0.91 | 2.66 | 4.87E-03 | 3.25E-02 | Positive |
| Adenosined | 312.09640 | 2.73 | 11.02 | 5.63E-03 | 4.80E-02 | Negative |
| Guanosine d | 282.08565 | 3.20 | 6.69 | 9.97E-03 | 4.36E-02 | Negative |
| 4-Dodecylbenzenesulfonic acidc | 325.18587 | 23.19 | 2.01 | 1.08E-02 | 4.36E-02 | Negative |
| L-Methionined | 150.05809 | 1.43 | 1.79 | 1.09E-02 | 4.23E-02 | Positive |
| L-Glutamated | 148.06014 | 0.91 | 4.82 | 1.25E-02 | 4.40E-02 | Positive |
| Adenosine diphosphate ribosec | 558.06761 | 0.98 | 1.69 | 1.28E-02 | 4.36E-02 | Negative |
| Ursodeoxycholic acidc | 391.28344 | 21.98 | 3.95 | 1.51E-02 | 4.59E-02 | Positive |
| Phosphoglycolic acidc | 156.99040 | 15.55 | 2.32 | 1.67E-02 | 4.62E-02 | Positive |
| β-Alaninec | 134.04642 | 1.18 | 4.37 | 1.97E-02 | 4.41E-02 | Negative |
| Uread | 159.02749 | 1.56 | 2.27 | 2.03E-02 | 4.82E-02 | Positive |
| Stearic acidd | 283.26555 | 21.64 | 1.14 | 2.08E-02 | 4.47E-02 | Negative |
| Cholined | 104.10728 | 0.89 | 5.83 | 2.21E-02 | 4.90E-02 | Positive |
| Glutaminylhydroxyprolinec | 258.10961 | 0.90 | 4.61 | 2.26E-02 | 4.87E-02 | Positive |
| O-Succinyl-L-homoserinec | 218.06749 | 2.35 | 1.03 | 2.32E-02 | 4.47E-02 | Negative |
| 2′,3′-Cyclic cytidine monophosphatec | 304.03553 | 1.00 | 1.41 | 2.40E-02 | 4.51E-02 | Negative |
| Putrescinec | 89.50707 | 23.35 | 2.56 | 2.41E-02 | 4.94E-02 | Positive |
| Hypoxanthined | 137.04560 | 1.56 | 3.39 | 2.73E-02 | 4.98E-02 | Positive |
| L-Threonined | 120.06557 | 0.91 | 1.13 | 2.82E-02 | 4.98E-02 | Positive |
| Spermidined | 146.16493 | 0.73 | 5.49 | 3.57E-02 | 4.98E-02 | Positive |
| Flavin adenine dinucleotide (FAD)c | 784.15553 | 5.59 | 1.40 | 3.61E-02 | 4.53E-02 | Negative |
| Uridine diphosphate-N-acetylglucosaminec | 606.07806 | 0.99 | 9.86 | 3.62E-02 | 4.66E-02 | Negative |
| Phosphohydroxypyruvic acidc | 185.16457 | 1.92 | 1.36 | 4.08E-02 | 4.98E-02 | Positive |
| dGuanosine triphosphate (dGTP)c | 505.99113 | 2.01 | 4.26 | 4.20E-02 | 4.66E-02 | Negative |
| Adenylosuccinatec | 462.06931 | 3.86 | 5.84 | 4.32E-02 | 4.86E-02 | Negative |
| Glycerophosphocholinec | 258.10964 | 1.45 | 1.80 | 4.83E-02 | 4.98E-02 | Positive |
a
p-values are calculated from a one-way ANOVA.
bFDR value was obtained from the adjusted p-value using Benjamini–Hochberg method.
cRepresents metabolites that were identified by the MS/MS spectrum.
dRepresents metabolites that were identified by commercial standards.