Table 2.

Transcriptomic and functional genomic support for candidate mediators of low-temperature rescue of ΔF508-CFTR trafficking.

Symbol	Transcriptomics (LowTmp-Meta)			Functional Genomics
	LogFC ± SEM	AdjP	Direction	CFG
PSMD9	1.21 ± 0.47	2.7E − 2	Up	Positive19
NDUFAF5	1.15 ± 0.10	0.0E − 0	Up	Positive20
COX4NB	0.91 ± 0.16	2.0E − 4	Up	Positive21
EDN1	0.87 ± 0.34	2.8E − 2	up	positive20
AKAP8	0.85 ± 0.14	2.0E − 4	Up	Positive22
DNAJB2	− 0.63 ± 0.14	2.1E − 4	Down	Negative23
UBAC2	− 0.63 ± 0.09	2.0E − 4	Down	Negative21
DNAJA1	− 0.68 ± 0.10	2.0E − 4	Down	Negative23
SEC22B	− 0.68 ± 0.07	0.0E − 0	Down	Negative24
MET	− 0.69 ± 0.15	2.0E − 4	Down	Negative25
PANK1	− 0.72 ± 0.15	2.0E − 4	Down	Negative25
DNAJA3	− 0.76 ± 0.11	2.0E − 4	Down	Negative23
GTSE1	− 0.79 ± 0.08	0.0E − 0	Down	Negative22
UBE4B	− 0.91 ± 0.14	2.0E − 4	Down	Negative23
HSPA1A	− 1.29 ± 0.16	2.0E − 4	Down	Negative7
HSPA8	− 1.48 ± 0.33	2.1E − 4	Down	Negative7,23
RNASEL	− 1.57 ± 0.25	2.0E − 4	Down	Negative26

Direction column shows the sign of differential expression in the LowTmp-Meta signature. The CFG column shows the sign of each gene’s net effect on CFTR trafficking based on the referenced study, i.e. positive indicates membership in the CFG⁺ set, and negative indicates membership in CFG⁻.

LogFC logarithm (base 2) of the fold change, SEM standard error of the mean, AdjP adjusted p-value, CFG CFTR Functional Genomics.