Fig. 1.
The percentage changes over time in organ microRNA expression after treatment of Dicerflox/flox mice with AAV8 vector expressing or not expressing Cre Recombinase (Cre). Schematic for study design is presented. In graphs, for each organ, the expression of microRNAs is expressed as a percentage of the untreated Dicerflox/flox mice (baseline). Data are normalised to U6. Filled symbols represent mice receiving AAV8-Cre. Unfilled symbols represent AAV8-null. Symbols represent the time point median and the error bars define the inter-quartile range. N=20 for each AVV8/microRNA combination (N=5 for each time point). Linear regression was performed then for each microRNA Cre treatment was compared to null treatment to determine whether slopes were significantly different.