Fig. 3.

Urinary extra-cellular vesicles (ECVs) contain miR-122, which was significantly increased in patients with paracetamol-induced acute liver injury. Urine was collected from patients who had taken a paracetamol overdose that required treatment but did not cause liver injury ('No liver injury') and patients with liver injury (ALT>1000U/L). ECVs were isolated by ultra-centrifugation. MicroRNA concentration was measured and expression normalised by urinary creatinine. Statistical significance was determined by Mann-Whitney Test. Data are represented individual patients with bars representing median and IQR (N=4-20 per group).