Table. Association Between Treatment Response and Proximity to Personalized and Group Average Stimulation Target Sites^a.

Stimulation target	x, mm	y, mm	z, mm	R	P value
Personalized target	NA	NA	NA	−0.60	<.001
Group average targetsb
5-cm Average1	−41	16	54	0.13	.74
Beam F3 average3	−43	46	32	−0.22	.14
5-cm-Method–derived nonresponders (posterior-medial position)	−41	17	55	0.13	.74
5-cm-Method–derived responders (antero-lateral position)	−46	23	49	0.09	.66
EEG F3 TMS target	−37	26	49	0.16	.78
BA 9/46 junction TMS target #1	−46	45	38	−0.17	.21
BA 9/46 junction TMS target #2	−50	30	36	−0.02	.46
BA9 definition	−36	39	43	0.17	.79
BA46 definition	−44	40	29	−0.25	.11
SGC-FC–derived group target #11	−44	38	34	−0.10	.32
SGC-FC–derived group target #21	−38	44	26	−0.15	.23
SGC-FC–derived group target #12	−42	44	30	−0.23	.13
SGC-FC–derived group target (present work; HCP dataset, N = 2000 MRI scans)	−41	43	27	−0.25	.11

Abbreviations: BA, Brodmann area; EEG, electroencephalography; FC, functional connectivity; HCP, Human Connectome Project; MRI, magnetic resonance imaging; NA, not applicable; SGC, subgenual cingulate cortex; TMS, transcranial magnetic stimulation.

^aAssociations were tested using Spearman rank-order correlation. Targets specified in Montreal Neurological Space coordinates.

^bFor further detail regarding coordinates, refer to Fox et al¹ and Cash et al.⁴