Table 2. Risk of Heart Failure (HF) in Individuals in the Copenhagen General Population Study and the Copenhagen City Heart Study by Transthyretin Percentile at Baseline.
| Characteristic | HR (95% CI) | ||
|---|---|---|---|
| ≤5th Percentile | >5th-95th Percentile | >95th Percentile | |
| Copenhagen General Population Study | |||
| No. | 468 | 8643 | 471 |
| Incident HF, No. (%) | 32 (6.8) | 387 (4.5) | 22 (4.7) |
| Covariates | |||
| Age and sexa | 1.7 (1.2-2.5) | 1 [Reference] | 1.3 (0.9-2.1) |
| Age, sex, and hsCRPb | 1.6 (1.1-2.3) | 1 [Reference] | 1.4 (0.9-2.1) |
| Multivariable without hsCRPc | 1.6 (1.1-2.4) | 1 [Reference] | 1.2 (0.8-2.0) |
| Multivariable with hsCRPd | 1.6 (1.1-2.3) | 1 [Reference] | 1.3 (0.8-2.1) |
| Copenhagen City Heart Study | |||
| No. | 365 | 6654 | 366 |
| Incident HF, No. (%) | 76 (20.8) | 991 (14.9) | 55 (15.0) |
| Covariates | |||
| Age and sexa | 1.5 (1.2-1.9) | 1 [Reference] | 1.2 (0.9-1.5) |
| Age, sex, and hsCRPb | 1.4 (1.1-1.8) | 1 [Reference] | 1.2 (0.9-1.6) |
| Multivariable without hsCRPc | 1.4 (1.1-1.7) | 1 [Reference] | 1.2 (0.9-1.6) |
| Multivariable with hsCRPd | 1.3 (1.1-1.7) | 1 [Reference] | 1.2 (0.9-1.6) |
Abbreviations: HR, hazard ratio; hsCRP, high-sensitivity C-reactive protein.
a
Adjusted by age and sex.
b
Adjusted by age, sex, and log-transformed hsCRP level.
c
Adjusted by age, sex, body mass index, lipid-lowering therapy, hypertension, alcohol intake, smoking (pack-years), physical inactivity, alanine transaminase level, albumin level, cholesterol level, triglycerides level, and creatinine level.
d
Adjusted by age, sex, body mass index, lipid-lowering therapy, hypertension, alcohol intake, smoking (pack-years), physical inactivity, alanine transaminase level, albumin level, cholesterol level, triglycerides level, creatinine level, and log-transformed hsCRP level.