Table 4.
Univariable and multivariable Cox analysis of factors associated with OS of intrahepatic cholangiocarcinoma
| Variable | Univariable analysis | Multivariable analysis Pathology OS model |
Multivariable analysis Imaging OS model |
|||
| HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
| PD-1 | 2.930 (1.793 to 4.789) | <0.001 | 3.347 (2.007 to 5.581) | <0.0001 | ||
| PD-L1 | 1.867 (1.134 to 3.074) | 0.017 | 1.868 (1.127 to 3.097) | 0.015 | ||
| Sex | 1.165 (0.715 to 1.898) | 0.539 | ||||
| Age | 0.997 (0.977 to 1.017) | 0.756 | ||||
| Pathology | 1.130 (0.693 to 1.844) | 0.625 | ||||
| Diameter | 1.134 (0.849 to 1.516) | 0.389 | ||||
| No | 2.203 (1.040 to 4.664) | 0.060 | ||||
| Adjacent organ invasion | 1.451 (0.776 to 2.714) | 0.263 | ||||
| Nerve invasion | 2.313 (1.334 to 4.010) | 0.005 | ||||
| Satellite nodule | 1.745 (0.990 to 3.076) | 0.067 | ||||
| Necrosis | 1.592 (0.867 to 2.923) | 0.153 | ||||
| Intravascular tumour thrombus | 1.715 (0.740 to 3.975) | 0.242 | ||||
| Lymph node metastasis | 1.827 (1.090 to 3.063) | 0.028 | ||||
| Surgical margin | 0.845 (0.365 to 1.956) | 0.687 | ||||
| ALT | 1.124 (0.665 to 1.901) | 0.664 | ||||
| AST | 1.285 (0.774 to 2.133) | 0.339 | ||||
| GGT | 1.952 (1.109 to 3.436) | 0.015 | ||||
| CEA | 1.918 (1.177 to 3.123) | 0.008 | 2.485 (1.502 to 4.111) | 0.0004 | 1.946 (1.189 to 3.186) | <0.001 |
| CA-199 | 1.573 (0.914 to 2.708) | 0.092 | ||||
| AFP | 0.606 (0.277 to 1.329) | 0.182 | ||||
| Cirrhosis | 1.169 (0.625 to 2.187) | 0.630 | ||||
| Hepatitis B | 0.642 (0.361 to 1.144) | 0.119 | ||||
| Position | 0.952 (0.641 to 1.413) | 0.806 | ||||
| Shape | 1.864 (1.115 to 3.117) | 0.015 | ||||
| Margin | 2.689 (1.599 to 4.523) | <0.001 | ||||
| Peritumoural bile duct dilatation | 2.400 (1.445 to 3.988) | <0.001 | ||||
| Hepatic lobe atrophy | 2.718 (1.544 to 4.784) | 0.001 | ||||
| Capsular retraction | 1.946 (1.192 to 3.179) | 0.008 | ||||
| Imaging classification | 3.583 (1.819 to 7.057) | <0.001 | 2.653 (1.317 to 5.343) | 0.006 | ||
| Target sign in T2WI | 0.376 (0.185,0.761) | 0.002 | ||||
| Target sign in DWI | 0.509 (0.298 to 0.870) | 0.010 | ||||
| Enhancement patterns | 0.246 (0.125 to 0.486) | <0.001 | ||||
| Intratumour vascularity | 1.051 (0.520 to 2.125) | 0.890 | ||||
| Intra-tumoural separate | 0.857 (0.528 to 1.390) | 0.532 | ||||
| Radscore | 4.419 (2.743 to 7.118) | <0.001 | 3.7213 (2.210 to 6.265) | <0.0001 | ||
Data in parentheses are 95% CIs.
The independent predictors in the pathology-based and imaging-based OS predicting models were summarised.
Bold values indicate that these are statistically significant in univariable analysis.
AFP, a-fetoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CA-199, cancer antigen 199; CEA, carcinoembryonic antigen; GGT, γ-glutamyl transpeptidase; OS, overall survival; PD-1, programmed cell death protein 1; PD-L1, programmed cell death protein ligand 1; Radscore, radiomics score.