Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 25;8(2):e001513. doi: 10.1136/jitc-2020-001513

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

PMC Copyright notice

T cell profiles associated with a durable response to the programmed cell death-1 (PD-1) inhibitor. To investigate the T cell profiles that may be associated with a durable response to the PD-1 inhibitor, we compared the proportions of hCD4+ or hCD8+ T cells between durable and non-durable responders. (A and B) hCD4+ or hCD8+ T cells were analyzed using tumor tissue (A) and blood (B) by flow cytometry. Representative flow cytometry plots from a mouse in each group are shown. Dot plots represent average numbers of hCD8+ and hCD4+ cells in PBS group, durable responders, or non-durable responders. P values were calculated by analysis of variance (ANOVA) test, and post-hoc p values were calculated by least significant difference (LSD) test. Data are presented as mean±SD. ns, not significant. (C) Immunohistochemistry analysis of tumor-infiltrating T lymphocytes (ie, hCD8+ or hCD4+ T cells) using mouse tumor tissues. H&E images were collected at ×200 magnification and immunohistochemical images were collected at ×400 magnification. P values were calculated by ANOVA test after counting positive cells in five random, non-overlapped fields and post-hoc p values were calculated by LSD test. Data are presented as mean±SD.