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. 2020 Nov 25;8(2):e001513. doi: 10.1136/jitc-2020-001513

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Serum human cytokine profiles associated with a durable response to the programmed cell death-1 (PD-1) inhibitor. Serum human cytokines, including TNF-α (A), IL-6 (B), and IFN-γ (C) were analyzed with the bead-based assay LEGENDplex at weeks 4, 8 and 10 from PD-1 inhibitor treatment in order to determine if an early immunological reaction could predict a durable response to the PD-1 inhibitor. P values were calculated by analysis of variance (ANOVA) test, and post-hoc p values were calculated by LSD test. Data are presented as mean±SD. (D) Response of serum cytokine by PD-1 inhibitor according to the time point. Cytokine level with time was represented as relative fold change (0 week; 1).