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. 2020 Nov 25;40(11):BSR20193053. doi: 10.1042/BSR20193053

Figure 2. miR-221 expression is up-regulated in CSF and miR-221 inhibits EPC proliferation and migration.

Figure 2

(A) We examined miR-221 expression in EPCs from 10 normal controls and 20 patients with CSF by real-time PCR. (B) EPCs were treated with atorvastatin (Ato) and examined for miR-221 expression. (C) miR-221 expression in EPCs after transfection of miR-221 mimics or inhibitor, as confirmed by real-time PCR. (D) MTT assays to determine cell viability of miR-221-overexpressing or miR-221-silenced EPCs. (E) Transwell assays to determine cell migration of miR-221-overexpressing or miR-221-silenced EPCs. (F) Tube formation assay to detect the angiogenic capacity of miR-221-overexpressing or miR-221-silenced EPCs. *P<0.05, **P<0.01.