Figure 4.

Validation of MDM2 and hTEAD4 binders. a) Docking of 8 into the MDM2–p53 interaction site. b) Effect of the off‐DNA‐synthesized 8 bound to MDM2. c) Chemical structures of biologically evaluated compounds 9, 12–15. d) Validation of compound binding to hTEAD4 by nanoDSF. e) Inhibition of palmitic acid binding to the hTEAD4 central pocket measured by fluorescence polarization. f) Inhibition of YAP binding to hTEAD4 measured by fluorescence polarization. g) Evaluation of the cellular activity of 9 by measurement of CTGF transcript expression levels.