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. 2020 Aug 10;35(11):2179–2192. doi: 10.1002/jbmr.4119

Table 1.

Study Design

Group Animals (n/group) Treatment Duration to necropsy (weeks)
Group 1 6 Negative control group (no ZOL + Sx + no ZOL) 20 (12 + 8)
Group 2 6 Positive control/MRONJ group (ZOL + tooth extraction + ZOL) 20 (12 + 8)
Group 3 12 Preventive measures group (ZOL + Sx + PM + ZOL + AB) 20 (12 + 8)
Group 4 12 Prevention group (ZOL + drug holiday + Sx + PM + drug holiday + AB) 26 (12 + 6 + 8)

AB = antibiotics; PM = preventive measures (group 3 and group 4) in form of preventive wound management during tooth extraction surgery (resection of sharp bone edges, tension‐free mucoperiosteal coverage) and systemic application of AB; Sx = surgical tooth extraction; ZOL = antiresorptive treatment in form of zoledronate.