Figure 1.

Fenebrutinib plasma concentration‐time profiles in healthy volunteers receiving 100 mg fenebrutinib, or a 200 mg itraconazole pretreatment, once daily × 3 days followed by 100 mg fenebrutinib. Itraconazole did not produce the expected increase in C_max, but still decreased the slope of the elimination phase. T_max was also delayed in the itraconazole arm. (n = 14–16 healthy volunteers per arm). C_max, maximum plasma concentration; ITZ, itraconazole; T_max, time to reach maximum plasma concentration.