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. 2020 Jul 18;108(6):1224–1232. doi: 10.1002/cpt.1943

Figure 3.

Figure 3

Fenebrutinib (a) plasma concentration‐time profiles and (b) cumulative recovery in feces in pentagastrin‐pretreated dogs receiving a 100 mg fenebrutinib tablet, or a 100 mg fenebrutinib tablet with 0.8 g, 2 g, or 8 g of HP‐β‐CD. The 8 g dose of HP‐β‐CD was the same amount that was administered in the itraconazole DDI study. Cmax and AUC decreased, recovery in feces increased, and Tmax was prolonged, all in an HP‐β‐CD dose‐dependent manner (n = 4 dogs per group). AUC, area under the concentration‐time curve; Cmax, maximum plasma concentration; DDI, drug–drug interaction; HP‐β‐CD, hydroxypropyl‐β‐cyclodextrin; Tmax, time to reach maximum plasma concentration.