Table 1.

Pharmacokinetic parameters compared between the control and HP‐β‐CD arms from the pharmacokinetic study in pentagastrin‐pretreated dogs

Fenebrutinib Dose (mg)	HP‐β‐CD Administered (g)	AUC 0‐∞ (µg/hour/mL)	Tmax (hour)	Cmax (µg/mL)	Fenebrutinib recovered in feces (mg)
100	0	28.9 ± 6.98	0.875 ± 0.250	3.94 ± 0.225	3.48 ± 0.681
100	0.8	17.4 ± 6.92*	1.38 ± 1.11	2.09 ± 0.243*	11.2 ± 2.39
100	2	8.38 ± 1.94*	2.00 ± 1.15	1.11 ± 0.142*	15.6 ± 8.99*
100	8	4.46 ± 2.07*	3.00 ± 0.00*	0.447 ± 0.204*	22.7 ± 7.76*

AUC, area under the concentration‐time curve; C_max, maximum plasma concentration; HP‐β‐CD; hydroxypropyl‐β‐cyclodextrin; T_max, time to reach maximum plasma concentration.

^*Denotes P < 0.05 between control and treatment arm using one‐way ANOVA (analysis of variance) with Bonferroni’s multiple comparisons test.