. 2020 Jun 27;108(5):1098–1106. doi: 10.1002/cpt.1917

Table 3.

Pharmacokinetic parameter estimates and SIR results relating to clearance

Compound		Parameter
Compound		Cl, L/h ^a	PNA on Cl, %/h	TEMP on Cl, %/°C
Morphine	Estimate	0.811	0.540	6.83
Morphine	SIR 95% CI ^b	0.707–0.937	0.371–0.750	5.16–8.34
Midazolam	Estimate	0.511	0.540	6.83
Midazolam	SIR 95% CI ^b	0.387–0.620	0.371–0.750	5.16–8.34
OHM ^c	Estimate	1.72	0.540	6.83
OHM ^c	SIR 95% CI ^b	1.43–2.05	0.371–0.750	5.16–8.34
M3G ^c	Estimate	0.241	1.23	NA
M3G ^c	SIR 95% CI ^b	0.220–0.269	1.03–1.43	NA
M6G ^c	Estimate	0.765	1.23	NA
M6G ^c	SIR 95% CI ^b	0.697–0.854	1.03–1.43	NA
HMG ^c	Estimate	0.111	1.23	NA
HMG ^c	SIR 95% CI ^b	0.0977–0.126	1.03–1.43	NA
Amoxicillin	Estimate	0.178 ^d	1.23	NA
Amoxicillin	SIR 95% CI ^b	0.159–0.196	1.03–1.43	NA
Benzylpenicillin	Estimate	0.359 ^d	1.23	NA
Benzylpenicillin	SIR 95% CI ^b	0.297–0.423	1.03–1.43	NA
Gentamicin	Estimate	0.108 ^d	1.23	NA
Gentamicin	SIR 95% CI ^b	0.0968–0.120	1.03–1.43	NA
Lidocaine	Estimate	0.937	1.23	NA
Lidocaine	SIR 95% CI ^b	0.783–1.11	1.03–1.43	NA
MEGX ^c	Estimate	1.51	1.23	NA
MEGX ^c	SIR 95% CI ^b	0.991–2.06	1.03–1.43	NA
Phenobarbital	Estimate	0.00930	NA	NA
Phenobarbital	SIR 95% CI ^b	0.00785–0.0111	NA	NA

BW, body weight; CI, confidence interval; Cl, clearance; GA, gestational age; HMG, hydroxymidazolam glucuronide; M3G, morphine‐3‐glucuronide; M6G, morphine‐6‐glucuronide; MEGX, monoethylglycinexylidide; NA, not applicable; OHM, 1‐hydroxymidazolam; PNA, postnatal age; SIR, sampling importance resampling; TEMP, body temperature.

^{^a}

Estimates for a neonate with BW 3.5 kg, GA 280 days, PNA 0 hours and TEMP 36.5°C.

^{^b}

Six iterations; no. of samples 4,000, 4,000, 4,000, 4,000, 4,000, and 4,000; no. of resamples 250, 250, 250, 250, 250, and 1,000.

^{^c}

All metabolite estimates are relative to their formation fraction.

^{^d}

Estimated clearance in the central compartments. Peripheral compartment estimates are included in the Appendix.