Table 2.
Characteristics of patients included in the analysis
| Patient characteristics | |
| Number of patients (n) | 12 |
| Postnatal age (weeks) | 13.1 (1.3–218.6) |
| Weight (kg) | 5.6 (3.1–17.0) |
| Gender (M/F) | 8/4 |
| Reason for admission (n) | |
| Respiratory failure | |
| Pneumonia/bronchiolitis | 3 |
| Congenital cardiac abnormality | 2 |
| Pulmonary hypertension | 1 |
| Post cardiac surgery | 5 |
| Status epilepticus | 1 |
| Disease severity scores | |
| PELOD | 6.5 (0–20) |
| Number of organs failing on study day | 1 (0–2) |
| PRISM | 18 (11–28) |
| PIM | −3.1 (−4.7 to −0.6) |
| Laboratory values at day of administration [14C]midazolam | |
| Plasma creatinine (µmol/L) | 38 (25–63) |
| AST (U/L) | 53 (16–309) |
| ALT (U/L) | 17 (7–114) |
| CRP (mg/L) | 21 (3–123) |
Data are presented as median (range) or number.
ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C‐reactive protein; PELOD, Pediatric Logistic Organ Dysfunction; PIM, Pediatric Index of Mortality; PRISM, Pediatric Risk of Mortality.