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. 2020 Aug 6;50(11):1783–1797. doi: 10.1002/eji.202048644

Figure 3.

Figure 3

MAIT cells in renal tissue phenotypically differ from circulating MAIT cells. Scatterplots of the percentage of MAIT cells expressing of (A) IL‐7Rα and KLRG1 (B) T‐bet, eomes, granzyme B, and ki‐67 (C) CXCR3 and CXCR6 in healthy PBMCs, RTRs pretransplantation PBMCs, paired PBMCs post‐transplantation, healthy kidney MNCs, and TX kidney MNCs. The following statistical comparisons were made: kidney MNCs (both healthy and TX) versus PBMCs (healthy and RTRs post‐transplantation) (Mann Whitney U‐test); healthy kidney versus TX kidney MNCs (Mann Whitney U‐test); RTRs pretransplantation versus healthy PBMCs (Mann Whitney U‐test); RTRs pre‐ versus post‐transplantation PBMCs (Wilcoxon signed rank test). The horizontal dash represents the median. Only significant p‐values are displayed: *p < 0.05, **p ≤ 0.01, ***p ≤ 0.001. Data shown represent nine flow cytometry experiments with n = 2, 4, 9, 2, 21, 10, 16, 15, and 12 individuals. (A) A total of 79 unique individuals are shown (healthy PBMC = 20, RTRs pre‐/post‐ transplantation = 21, healthy kidney = 5, and TX kidney = 12). (B) A total of 76 unique individuals are shown (healthy PBMC = 20, RTRs pre‐/post‐transplantation = 21, healthy kidney = 3, and TX kidney = 11). (C) A total of 80 unique individuals are shown (healthy PBMCs = 20, RTRs pre‐/post‐transplantation = 21, healthy kidney = 4, and TX kidney = 14). RTRs: renal transplant recipients; PBMCs: peripheral blood mononuclear cells; MNCs: mononuclear cells; TX: transplant.