TABLE 1.
Patient characteristics
| tIEF selected samples (n = 961) | QTOF‐MS selected samples (n = 149) | ||||
|---|---|---|---|---|---|
| LTx (n = 511) | CLD (n = 450) | LTx (n = 76) | CLD (n = 34) | HC (n = 39) | |
| Mean age (years) | 48.5 (SD 12.2) | 50.0 (SD 15.5) | 52.6 (SD 12.0) | 51.8 (SD 13.2) | 47.1 (SD 14.2) |
| Male sex | 283 (55.4%) | 211 (46.9%) | 50 (65.8%) | 15 (44.1%) | 21 (53.8%) |
| Etiology | |||||
| Acute liver failure | 38 (7.4%) | 2 (0.4%) | 1 (1.3%) | 0 | n.a. |
| Alcoholic liver disease | 121 (23.7%) | 20 (4.4%) | 35 (46.1%) | 6 (17.6%) | n.a. |
| Auto‐immune hepatitis | 39 (7.6%) | 152 (33.8%) | 3 (3.9%) | 15 (44.1%) | n.a. |
| Cholestatic liver disease | 157 (30.7%) | 42 (9.3%) | 11 (14.5%) | 0 | n.a. |
| Cryptogenic cirrhosis | 54 (10.6%) | 20 (4.4%) | 10 (13.2%) | 1 (2.9%) | n.a. |
| Metabolic disease | 26 (5.1%) | 7 (1.6%) | 7 (9.2%) | 0 | n.a. |
| NASH | 10 (2.0%) | 36 (8.0%) | 0 | 3 (8.8%) | n.a. |
| Other | 61 (11.9%) | 36 (8.0%) | 8 (10.5%) | 2 (5.9%) | n.a. |
| Unknown | 5 (1.0%) | 5 (1.1%) | 1 (1.3%) | 0 | n.a. |
| Gilbert | — | 25 (5.6%) | 0 | 2 (5.9%) | n.a. |
| Viral hepatitis | — | 94 (20.9%) | 0 | 5 (14.7%) | n.a. |
| DILI | — | 11 (2.4%) | 0 | 0 | n.a. |
Abbreviations: CLD, chronic liver disease; DILI, drug induced liver injury; LTx, liver transplant recipient; HC, healthy controls; n.a., not applicable; NASH, nonalcoholic steatohepatitis.