Table 2.
Demographics and Disease Characteristics for Pharmacokinetic‐Evaluable Patients Summarized for Categorical and Continuous Covariates
| Covariate | Value |
|---|---|
| Patients in each study, n (%) | |
| NCT01492088 | 36 (42.9) |
| ADA positive | 10 (27.8) |
| NCT00430846 | 48 (57.1) |
| ADA positive | 3 (6.3) |
| Age (years) | |
| Median (range) | 25.65 (7.65‐87.24) |
| Mean (SD) | 27.59 (16.76) |
| Adult age group, n (%) | 50 (59.5) |
| Pediatric age group, n (%) | 34 (40.5) |
| Sex, n (%) | |
| Male | 54 (64.3) |
| Female | 30 (35.7) |
| Race, n (%) | |
| White | 73 (86.9) |
| Black | 5 (6.0) |
| Asian | 4 (4.8) |
| Not reported | 2 (2.4) |
| Ethnicity, n (%) | |
| Not Hispanic | 71 (84.5) |
| Hispanic | 4 (4.8) |
| Not reported | 9 (10.7) |
| Height (cm) | |
| Median (range) | 170.00 (123.7‐194.0) |
| Mean (SD) | 166.66 (15.96) |
| Weight (kg) | |
| Overall median (range) | 66.70 (21.2‐153.8) |
| Overall mean (SD) | 68.41 (25.83) |
| Pediatric median (range) | 49.45 (21.20‐87.00) |
| Pediatric mean (SD) | 49.51 (17.60) |
| Adult median (range) | 77.90 (44.90‐153.80) |
| Adult mean (SD) | 81.26 (22.47) |
| BMI, kg/m2 | |
| Overall median (range) | 22.66 (12.94‐44.94) |
| Overall mean (SD) | 23.95 (6.85) |
| Pediatric median (range) | 18.36 (12.74‐32.41) |
| Pediatric mean (SD) | 19.59 (4.88) |
| Adult median (range) | 26.13 (16.90‐44.94) |
| Adult mean (SD) | 26.91 (6.43) |
| BSA (m2) | |
| Overall median (range) | 1.80 (0.87‐2.81) |
| Overall mean (SD) | 1.76 (0.40) |
| Pediatric median (range) | 1.49 (0.87‐2.02) |
| Pediatric mean (SD) | 1.46 (0.32) |
| Adult median (range) | 1.94 (1.43‐2.81) |
| Adult mean (SD) | 1.96 (0.30) |
| Disease, n (%) | |
| HL | 63 (75.0) |
| sALCL | 17 (20.2) |
| Other | 4 (4.8) |
| Albumin, g/L | |
| Median (range) | 4.77 (0.82‐19.08) |
| Mean (SD) | 5.94 (3.89) |
| ALT (U/L) | |
| Median (range) | 39.00 (22‐51) |
| Mean (SD) | 38.04 (6.46) |
| AST (U/L) | |
| Median (range) | 18.00 (5‐140) |
| Mean (SD) | 26.12 (24.22) |
| Bilirubin (µmol/L) | |
| Median (range) | 22.00 (8‐163) |
| Mean (SD) | 26.35 (19.46) |
| Creatinine (µmol/L) | |
| Median (range) | 6.00 (2‐20) |
| Mean (SD) | 7.44 (4.19) |
| CrCl (mL/min) | |
| Median (range) | 70.72 (25.00‐123.76) |
| Mean (SD) | 67.66 (24.69) |
ADA, antidrug antibody; ALT, alanine aminotransferase; AST, aspartate transaminase; BMI, body mass index; BSA, body surface area; CrCl, creatinine clearance; HL, Hodgkin lymphoma; sALCL, systemic anaplastic large‐cell lymphoma; SD, standard deviation.