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Representation of the KasA nanoDSF results. ΔTm is calculated from a dimethyl sulfoxide (DMSO)-treated KasA control. Chemical structures are depicted for those compounds with the most pronounced ΔTm. Many of the identified compounds share a similar indazole core, suggesting that this may be an important structural element responsible for binding to KasA. Interestingly, two of these compounds with the indazole core seem to destabilize KasA as opposed to stabilizing it.
