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. 2020 Nov 10;5(46):30274–30281. doi: 10.1021/acsomega.0c04795

Figure 1.

Figure 1

Determination of Qu. (A) HPLC analysis of Qu in MCF-7/ADR cells. MCF-7/ADR cells were incubated with Qu (50 μM) or Qu-SS-Gcc LNPs (50 μM) for 3 or 8 h: (a) determination of free Qu; (b, c) determination of intracellular Qu after treatment with Qu-SS-Gcc LNPs for 3 and 8 h, respectively; and (d, e) determination of intracellular Qu after treatment with Qu for 3 and 8 h, respectively. (B) Amount of intracellular Qu after incubation with Qu (50 μM) or Qu-SS-Gcc LNPs (50 μM) in different conditions for 6, 12, or 24 h (upper) and amount of intracellular Qu-SS-Gcc LNPs (50 μM) in different conditions for 6, 12, or 24 h (lower). (C) Rh-123 efflux of the MCF-7/ADR cells after treatment with MS SLNs (50 μM), Qu (50 μM), Qu-SS-Gcc LNPs (50 μM), or verapamil (20 μM) for 3 or 8 h. The error bars in the graphs represent the standard deviation (n = 3).