Table 1.

Roles of m⁶A regulators in breast cancer

m6A regulators	Role in cancer	Biological function	Target/signaling axis	Refs.
Writers
METTL3	Oncogene	Promote cell proliferation and growth	HBXIP/let-7g/METTL3/HBXIP	[60]
		Promote proliferation and migration		[62]
		Promote cell proliferation, tumor growth; Inhibit cell apoptosis	Bcl-2	[61]
METTL14	Oncogene	Promote proliferation and migration		[62]
		Promote cell migration and invasion	Has-miR-146a-5p	[76]
		Promote cell proliferation and colony formation and inhibit cell apoptosis	LNC942-METTL14-CXCR4/CYP1B1	[71]
	Tumor suppressor	Suppress cell viability, colony formation and migratory abilities		[64]
KIAA1429	Oncogene	Promote proliferation and migration	CDK1	[65]
Hakai	Tumor suppressor	Suppress cell proliferation and migration	ERα	[79]
Erasers
FTO	Oncogene	Promote cell proliferation, colony formation and metastasis	BNIP3	[67]
ALKBH5	Oncogene	Promote cell viability, colony formation and migratory abilities		[64]
		Increase the percentage of breast cancer stem cells	NANOG	[82]
		Promote metastasis from breast to lungs	NANOG and KLF4	[83]
	Tumor suppressor	Suppress proliferation and migration		[76]
Readers
YTHDF3	Oncogene	Independent prognostic factor for overall survival		[25]
hnRNPC	Oncogene	Promote cell proliferation and tumor growth	dsRNA-induced interferon response	[72]
hnRNPA2/B1	Oncogene	Promote cell proliferation, decrease apoptosis, and prolong the S phase of the cell cycle	STAT3 and ERK1/2 signaling pathway	[73]
	Tumor suppressor	Suppress EMT and metastasis	PFN2	[86]
IGF2BP	Oncogene	Promote stemness of breast cancer cells	Myc	[84]
eIF3m	Oncogene	Promote the cell proliferation, migration, invasion as well as suppress apoptosis in TNBC		[71]
eIF3g	Oncogene	Promote lymph node metastasis	hnRNPU, HSZFP36 and β-actin	[87]