Fig. 5.

LINC00152 promotes EMT and EC cell resistance to L-OHP by upregulating ZEB1. a–b cell survival rate after 72 h of treatment with different concentrations of L-OHP (0, 0.5, 1.0, 2.5, 5.0, 10.0 µM) in Kyse-150 and TE-1 cells detected by CCK-8 assay. c–d, the expression of E-cadherin, vimentin, cleaved PARP/PARP and cleaved Caspase 3/Caspase 3 proteins in Kyse-150 (c) and TE-1 cells (d) after 72 h treatment with 10.0 µM of L-OHP determined by Western blot analysis. # p < 0.05 vs. the si-ZEB1 group. Comparisons among multiple groups were conducted by ANOVA with Tukey’s post hoc test. Data at different time points and different concentrations were compared by repeated measures ANOVA. Data are presented as mean ± standard deviation of three technical replicates