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. 2020 Nov 26;17:60. doi: 10.1186/s12989-020-00390-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Diagram showing selected biological endpoints at 3 days (a) and 60 days (b) post-exposure to the different MWCNTs samples used in this study. Increasing distance away from the center indicates increasing biological response. In general, chemically purified MWCNTs and functionalized derivatives caused a greater increase in pro-inflammatory chemokines at 3 days post-exposure, while thermally purified MWCNTs and functionalized derivatives caused a greater increase in pro-fibrotic cytokines (OPN, CCL2) at 3 days and greater pulmonary toxicity (LDH, total protein), BAL lymphocytes, and numbers of granulomas at 60 days post-exposure