Table 2.
Peak severity of symptoms up to 6 h after consuming gluten
| Gluten reaction severity‡ | All | ||||||
|---|---|---|---|---|---|---|---|
| None | Very mild | Mild | Moderate | Severe | Very severe | ||
| Number of patients (%) | 8 (3) | 33 (11) | 65 (22) | 104 (35) | 54 (18) | 31 (10) | 295 |
| Median peak hourly severity of digestive symptoms rated each hour in the Global Symptom Survey† (interquartile range) | |||||||
| Absolute value | 0 (0–0) | 2 (1–2) | 2 (1–2) | 6 (5–6) | 8 (8–8) | 10 (9–10) | 5 (3–8) |
| Change from baseline | 0 (0–0) | 1 (1–2) | 1 (1–2) | 5 (5–6) | 8 (7–8) | 10 (9–10) | 5 (3–7) |
| Median peak hourly symptom score in modified CeD PRO† (interquartile range) | |||||||
| Nausea | 0 (0–0) | 1 (0–2) | 2 (1–4) | 5 (3–6) | 8 (7–9) | 10 (10–10) | 4 (2–8) |
| Diarrhoea | 0 (0–0) | 0 (0–0) | 0 (0–0) | 0 (0–1) | 1 (0–6) | 8 (1–10) | 0 (0–3) |
| Loose stool | 0 (0–0) | 0 (0–0) | 0 (0–1) | 0 (0–3) | 2 (0–8) | 8 (2–10) | 0 (0–3) |
| Cramping | 0 (0–1) | 1 (0–1) | 2 (1–3) | 4 (2–5) | 7 (4–8) | 8 (6–9) | 4 (1–6) |
| Pain | 0 (0–1) | 1 (0–1) | 2 (1–3) | 4 (3–5) | 6 (5–8) | 8 (6–9) | 4 (1–6) |
| Tiredness | 2 (0–3) | 2 (1–3) | 3 (2–5) | 6 (4–7) | 7 (7–8) | 6 (5–8) | 5 (3–7) |
| Bloating | 0 (0–0) | 2 (1–2) | 3 (2–3) | 5 (3–6) | 7 (5–7) | 5 (3–7) | 4 (2–6) |
| Gas | 0 (0–0) | 1 (1–2) | 2 (1–3) | 3 (2–4) | 4 (2–6) | 4 (1–7) | 2 (1–4) |
| Headache | 0 (0–0) | 1 (0–3) | 2 (0–4) | 4 (2–6) | 3 (1–8) | 2 (1–6) | 3 (1–5) |
‡Peak overall severity was the worst hourly descriptor rating reported by patients over 6 h after gluten challenge in the Global Symptom Survey for the question, “Overall, how would you rate the severity of your digestive symptoms in the past 1 h? (e.g. feeling or being sick, abdominal pain or cramps, feeling bloated, having loose stools or passing gas)”
†Whole number rating scale from 0 for no symptoms to 10 for worst possible symptoms