Table 3.
Number (%) of participants reporting a symptom as among their three most troubling symptoms after gluten challenge according to peak reaction severity
| Peak severity of global gastrointestinal symptoms (GloSS)‡ | Totalb | ||||||
|---|---|---|---|---|---|---|---|
| Nonea | Very milda | Milda | Moderatea | Severea | Very severea | ||
| Total patients | 8 (3) | 33 (11) | 65 (22) | 104 (35) | 54 (18) | 31 (11) | 295 (100) |
| Nausea | 1 (13) | 5 (15) | 29 (45) | 54 (52) | 32 (60) | 21 (72) | 142 (49) |
| Tiredness | 3 (38) | 16 (48) | 32 (50) | 50 (49) | 24 (45) | 3 (10) | 128 (44) |
| Abdominal pain/cramps | 1 (13) | 8 (24) | 24 (38) | 48 (47) | 24 (45) | 13 (45) | 118 (41) |
| Bloating | 0 | 15 (45) | 22 (52) | 43 (42) | 15 (28) | 1 (3) | 107 (37) |
| Headache | 1 (13) | 14 (42) | 24 (38) | 44 (43) | 16 (30) | 4 (14) | 103 (36) |
| Vomiting | 0 | 0 | 1 (2) | 13 (13) | 24 (45) | 26 (90) | 64 (22) |
| Gas | 0 | 8 (24) | 25 (39) | 21 (20) | 6 (11) | 0 | 60 (21) |
| Diarrhoea/loose stool | 0 | 1 (3) | 5 (8) | 12 (12) | 11 (21) | 14 (48) | 43 (15) |
| None | 5 (63) | 1 (3) | 0 | 1 (1) | 0 | 0 | 7 (2) |
| Others | 0 | 2 (6) | 3 (5) | 1 (1) | 0 | 0 | 6 (2) |
Participants’ responses to Q3 in the Global Symptom Survey, 6 h after gluten challenge, “What symptom/s overall have troubled you the most today, since having the food challenge?” Please select a maximum of 3 symptoms: A. none, B. abdominal pain/cramps, C. vomiting, D. nausea, E. diarrhoea/loose stool, F. gas (flatulence), G. bloating, H. tiredness, I. headache, J. others (please specify)
‡The peak overall severity was the worst hourly descriptor rating reported by patients over 6 h after gluten challenge in the Global Symptom Survey for the question, “Overall, how would you rate the severity of your digestive symptoms in the past 1 h? (e.g. feeling or being sick, abdominal pain or cramps, feeling bloated, having loose stools or passing gas)”
aPercentage of patients for each severity subgroup, e.g. none and very mild
bPercentage of all 295 patients