Table 1.
The expression profiles of miRNAs, lncRNAs, and circRNAs in keloid
| ncRNAs | Sample | Number (cases/controls) | DE ncRNAs (up/down) | Up-regulated ncRNAs verified by qRT-PCR | Down-regulated ncRNAs verified by qRT-PCR | KEGG enrichment analysis | Ref |
|---|---|---|---|---|---|---|---|
| MiRNAs | Skin tissue | 3/3 | 40 (27/13) | miR-370-3p | miR-204-5p |
Regulation of actin cytoskeleton pathway Yersinia infection pathway Proteoglycans in cancer pathway |
[37] |
| Skin tissue | 3/3 | 12 (6/6) | N/A | miR-194-3p | N/A | [31] | |
| Skin tissue | 3/3 | 264 (139/125) |
miR-199a-5p miR-21-5p miR-214-5p miR-424-5p |
miR-205-5p |
MAPK signaling pathway HIF-1 signaling pathway Prolactin signaling pathway |
[32] | |
| Skin tissue | 8/8 | 293 (168/125) | N/A | miR-199a-5p | N/A | [30] | |
| Skin tissue | 12/12 | 32 (23/9) |
miR-21 miR-4269 miR-382 |
miR-203 miR-205 miR-200c |
Cell cycle pathway MAPK pathway P53 pathway |
[28] | |
| Skin tissue | 5/5 | 74 (46/28) | N/A | miR-1224-5p | N/A | [76] | |
| Fibroblast | 3/3 | 9 (6/3) | miR-4328 |
miR-152 miR-145-5p miR-320c miR-30a-5p |
TGF-β pathway MAPK pathway Apoptosis and cell cycle pathway |
[29] | |
| Serum | 9/7 | 37 (17/20) |
miR-1225-5p miR195-5p, miR-513-5p |
miR-6801-3p miR-4254 miR-412-3p |
PI3K-Akt signaling pathway MAPK signaling pathway Ras signaling pathway |
[33] | |
| LncRNAs | Skin tissue | 3/3 | 319 (251/68) | lnc-CASP9-3 | lnc-GLB1L-1 |
ErbB pathway Phospholipase D pathway |
[37] |
| Skin tissue | 2/2 | 2227 (1224/1003) | N/A | N/A |
Cancer pathway Metabolic transcriptional misregulation pathway RAS pathway |
[41] | |
| Skin tissue | 4/4 | 30 (16/14) | LOC100271722 | HNF1A-AS1 |
Notch pathway Wnt pathway Hippo pathway |
[42] | |
| Skin tissue | 4/4 | 69 (38/31) |
CACNA1G-AS1 HOXA11AS LINC00312 |
RP11-91I11.1 AP001476.4 RP4-794H19.4 AC004074.3 |
Wnt pathway | [43] | |
| Skin tissue and Fibroblast | 5/5 and 3/3 | 3680 (2238/1442) and 5448 (2526/2922) |
ENST00000439703 uc003jox.1 |
N/A |
Wnt pathway PI3K-Akt pathway PPAR signaling pathway |
[39] | |
| Skin tissue | 3/3 | 2068 (1290/778) |
NONHSAT120157 NONHSAT062994 NONHSAT016933 NR 024360.1 FR39263 |
NONHSAT053431 ENST00000601148 TCONS 00022478 XR 244388.1 |
Focal adhesion pathway Metabolic pathway ECM-receptor interaction pathway |
[40] | |
| Skin tissue | 3/3 | 2513 (1731/782) |
ENST00000522743 NR-038439 uc0021fu.1 |
ENST00000521141 |
ECM-receptor interaction pathway Calcium pathway MRNA surveillance pathway |
[38] | |
| Skin tissue | 6/6 | 3469 (2479/990) |
ENSG00000251085 ENSG0000 0223749 ENSG0000 0258876 ENSG0000 0237548 |
ENSG0000 0268262 |
TNF pathway TGF-β pathway Jak-STAT pathway |
[49] | |
| CircRNAs | Fibroblast | 3/3 | 411 (206/205) |
circRNA-0008259 circRNA-0005480 |
circRNA-0002198 |
Focal adhesion pathway PI3K-Akt pathway Metabolic pathway |
[47] |
| Skin tissue | 3/3 | 76 (52/24) | N/A | circRNA-0057452, circRNA-0007482, circRNA-0020792, circRNA-0057342 circRNA-0043688 |
cAMP pathway Cell cycle pathway Cancer pathway |
[48] | |
| Skin tissue | 2/2 | 154 (81/73) | N/A | circRNA-0000994 |
Focal adhesion pathway Actin cytoskeleton pathway PI3K-Akt pathway |
[41] | |
| Skin tissue | 6/6 | 11 (10/1) |
circ17-50190326-50194041 circ17-50189167-50194626 circ17-50189858-50195330 circ17-50189167-50198002 |
circ11-33286412-33287511 circ2-72718102-72733118 |
ECM-receptor interaction pathway Gap junction pathway Protein digestion and absorption pathway |
[49] |
DE ncRNAs were verified to be mainly associated with multiple signaling pathways involved in proliferation, migration, apoptosis, and differentiation through high-throughput sequencing and bioinformatics analysis. Meanwhile, qRT-PCR verification is further methods of confirming the identified dysregulated ncRNAs. NA not available, DE differentially expressed, ncRNAs non-coding RNAs, miRNAs microRNAs, lncRNAs long non-coding RNAs, circRNAs circular RNAs; qRT-PCR quantitative reverse transcription-polymerase chain reaction, KEGG Kyoto Encyclopedia of Genes and Genomes