Fig. 2.

Specificity and sensitivity of a risk factor-based score for HBV vaccine responder status. An individual risk score (0–6 points) was calculated for each subject: i) BMI: normal BMI (0 points), BMI > 25–30 kg/m² (1 point), and BMI > 30 kg/m² (2 points); ii) Age: < 30 (0 points), 30–40 (1point), and > 40 (2 points); and iii) smoking status: non-smoker (0 points), 1–9 cigarettes a day (1 point), and > 9 cigarettes a day (2 points). Only subjects with complete datasets regarding these risk factors (n = 154: 24 NR (black), 36 LR (grey), 94 R (white)) were considered for this analysis. a Average score points in three groups are displayed. Box indicates median and IQR; whiskers indicate 5-95th percentile. b Receiver operating characteristic (ROC)- curve and AUC (Area under curve) of risk scores are displayed. Non-responders are shown in black, low-responders in grey and responders in white